A Note on the Photosensitivity of Phenothiazine Derivatives

Abstract

Propiomazine hydrochloride is designated by the following chemical names : ±10-( 2-dimethylaminopropyl) - 2 -propionylphenothiazine hydrochloride, and propionyl-promethazine hydrochloride. The most commonly used trade name is Largon Hydrochloride. Propiomazine hydrochloride is a yellow, practically odorless powder. hopiomazine hydrochloride can be identified by virtue of its characteristic IR , UV, and X-ray spectra. A series of microcrystalline derivative and color identification tests have been reported to detect and differentiate microgram quantities of propiomazine from other structurally related phenothiazine derivatives. Propiomazine hydrochloride is very stable in both the solid state and in buffered aqueous solutions exposed to long term accelerated thermal conditions which are protected from UV light and contain a suitable antioxidant system to exclude dissolved oxygen. Many paper chromatographic methods have been reported in the literature to permit the isolation and detection of propiomazine hydrochloride.