Abstract
Abstract Monoamine oxidase from guinea pig tissues oxidises 4-hydroxy-tryptamine, 6-hydroxytryptamine and 7-hydroxytryptamine at about 50–70 per cent of the rate of 5-hydroxytryptamine. For the rat liver the relative rate of oxidation of 6-hydroxytryptamine is less. 5-Methoxytryptamine and tryptamine are substrates for amine oxidase as good as, or better than 5-hydroxytryptamine, whereas iso-5-hydroxytryptamine and iso-tryptamine are oxidised less readily than 5-hydroxytryptamine and tryptamine. 5-Hydroxy-β-hydroxy-NN-dimethyltryptamine(β-hydroxybufotenine) does not seem to be a substrate for amine oxidase from guinea pig kidney.
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