Abstract
1. High Insulin Concentrations Repress Insulin Receptor Gene Expression in Calf Hepatocytes Cultured in Vitro Zhigang Zhang, Xiaobing Li, Guowen Liu, Li Gao, Changming Guo, Tao Kong, Hongbin Wang, Ruifeng Gao, Zhe Wang, Xinglin Zhu Cellular Physiology and Biochemistry CrossRef
Highlights
Insulin and IGF-2 play important roles in animal organism
Within 30 min of slaughter, 16 tissue types were collected from each calf: liver, subcutaneous adipose depots, Semitendinosus muscle, pancreas, kidney cortex, spleen, heart, lung, hypothalamus, mesenteric lymph node, aorta, duodenum, colon, pituitary, cerebral cortex and cerebellar cortex
The distribution of insulin receptor (InsR) mRNA in various tissues were shown in Figures 2 and 3
Summary
Insulin and IGF-2 play important roles in animal organism. Insulin takes part in promoting cell proliferation, differentiation, as well as protein, fat, glycogenInsR mRNA IN TISSUES OF NEONATAL HOLSTEIN CALVES synthesis. Insulin and IGF-2 play important roles in animal organism. Insulin takes part in promoting cell proliferation, differentiation, as well as protein, fat, glycogen. InsR mRNA IN TISSUES OF NEONATAL HOLSTEIN CALVES synthesis. Main effect of IGF-2 are promoting the growth and the role of insulinlike. The insulin receptor (InsR), like other protein hormone receptors, is localized to the plasma membrane. InsR is a tyrosine kinase that is composed of two α subunits and two β subunits linked by disulphide bonds. It acts as an enzyme that transfers phosphate groups from ATP to tyrosine residues on intracellular target proteins
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