Abstract
Intravenous infusion of prostaglandin A 1 (PGA 1, formerly PGE 1-217) (9-keto-15-hydroxy prosta-10,13-dienoic acid) 0.056 or 0.20 μg/kg/min during 20 minutes, into anesthetized dogs lowered the blood pressure and increased the heart rate. Infusion of PGE 1 produced qualitatively similar cardiovascular effects as PGA 1. However, the effects of PGA 1 on the cardiovascular system were usually quantitatively more pronounced than those produced by PGE 1. No consitent changes in the plasma levels of FFA, glycerol or blood glucose were seen during administration of PGA 1. Studies with rat adipose tissue in vitro showed that PGA 1 had less than 10 per cent of the lipolysis inhibiting activity of PGE 1.
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