Abstract
Abstract The treatment of rats with large doses of sodium salicylate induces a marked decrease in the 5-hydroxytryptamine level of the skin without depleting the stores in the ileum. After the addition of sodium salicylate to rat incubated skin, an increased release of 5-hydroxytryptamine into the surrounding fluid was noted in only 3 instances out of 10 using Vane's preparation of the rat fundus for the assay.
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