A Note on Further Experiments on the Effects of Meprobamate on Discrimination Performance in the Monkey

Abstract

Abstract A previous experiment (Gross and Weiskrantz, 1961) has shown that performance on a successive auditory discrimination task is impaired by injections of meprobamate. The present two brief experiments indicate that the drug also impairs simultaneous visual discrimination performance, although not to the same degree as found earlier for auditory discrimination. The original finding, therefore, cannot be attributed simply to unique features of the auditory discrimination situation, such as the “go—no-go” response contingency. Since neither overtraining nor drug habituation appears to be of great importance, it is suggested that the lesser effect of the drug in these experiments reflects the greater stability of visual than auditory habits in the monkey. Earlier work has shown that meprobamate and reserpine can cause a severe deterioration in auditory discrimination performance of monkeys (Gross and Weiskrantz, 1961). This result was taken as supporting a hypothesis, growing out of still earlier resea...