Abstract
A composite containing hydroxyapatite, graphene oxide and silver nanoparticles was obtained by performing a microwave-assisted hydrothermal method, a modified Hummer’s synthesis, and advantageously, by using dietary quercetin for silver nanoparticles formation and deposition. The pure constituents and composites were characterized by complementary physicochemical techniques, and evaluated in human keratinocytes and bacteria. In eukaryotic cells, it was found a dose-dependent toxic response that mainly depends on the presence of graphene oxide, and a superior cytocompatibility was observed for the samples containing hydroxyapatite. The ternary system showed a half maximal inhibitory concentration of about 116.8 μg/mL, ranged in a safety threshold. In comparison with silver nanoparticles alone, this ternary composite increased in 43% and 38% the inhibition zone for S. aureus and E. coli, respectively. Its minimum inhibitory concentration was found, respectively, close to 6.5 and 52.1 μg/mL, resulting in a fractional inhibitory concentration index < 0.5. Thus, this synergistic system can potentially be applied as a bactericidal for tissue replacement and surface coating.
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