A non-toxic poly(resorcinol) modified glassy carbon electrode for highly selective square wave voltammetry determination of aspirin in tablet formulations and human urine samples

Abstract

In this study, a sensitive square wave voltammetric method using poly(resorcinol) modified glassy carbon electrode (poly(reso)/GCE) was prepared for the determination of aspirin (ASA) in pharmaceutical tablet and biological fluid samples. CV and EIS were verify the modification of the GCE by a biosensor polymer that raised the electrocatalytic activity of poly(reso)/GCE towards an oxidation of ASA. Appearance of a single irreversible oxidative peak for ASA with fivefold current enhancement and much reduced potential at poly(reso)/GCE compared to bare GCE demonstrated catalytic property of the modifier. The peak current response with optimized experimental conditions at the poly(reso)/GCE exhibited a linear dependence with ASA concentration within the range 0.05–400.0 μM, with LoD 2.0 nM. The levels of ASA in four tablet brands ranged from 94.65 to 100.00% of their assigned values revealed the effectiveness of the developed method. The spike recovery results in pharmaceutical samples were ranged from 99.60 to 101.43% and urine samples 98.95% to 102.7%. Wider dynamic range, lower LoD, excellent spike recovery, and interference recovery results with errors <4.82% and good stability of the modifier, validated the potential applicability of the method based on poly(reso)/GCE for determination of ASA in real samples.