Year-end Sale % OFF 
Abstract
A series of 4a-methyl-3,4,4,4a-9-tetrahydrophenanthrene-2-carboxylic acids and 2-phosphinic acids has been prepared and evaluated in vitro as inhibitors of human recombinant steroid 5α-reductase. 7-Chloro-4a-methyl-3,4,4,4a-9-tetrahydrophenanthrene-2-carboxylic acid 5, is a marginally selective inhibitor of human type 2 steroid 5α-reductase (K i,app = 260 nM). The phosphinic acid compounds, 8 and 9, are weak inhibitors of types 1 and 2 steroid 5α-reductase.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
