Abstract
A rapid, sensitive, and simple high-performance liquid chromatography method is described for the direct analysis of aminopyrine in saliva. The detection limit was found to be 12 ng/ml of sample. Accuracy and precision were maintained with as little as 1 microliter of saliva. Thus the rate of elimination of aminopyrine has been monitored noninvasively in rats. The aminopyrine half-life was found to be 59.5 +/- 10.5 (SD) min. The half-life was independent of an aminopyrine dose between 50 and 200 mg/kg. In rats single intraperitoneal doses of SKF 525-A (20 mg/kg) produced increases in aminopyrine half-life and salivary aminopyrine concentration. Phenobarbital induction lowered the aminopyrine half-life to 33.2 +/- 8.5 min and the salivary aminopyrine concentration.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
