Abstract
AbstractFructosyl valine (Fru‐Val) is a glycosylated component of hemoglobin (HbA1c) that can serve as a diagnostic target for type 2 diabetes. While average blood glucose levels fluctuate significantly, the more stable levels of HbA1c can serve as a better long‐term diagnostic marker. Here a diagnostic system, incorporating an amperometric method, for detecting Fru‐Val (at +0.1 V vs. Ag/AgCl), using ferrocene boronic acid (FcBA) is presented. FcBA can complex diols, and has easily detectable redox properties. The boronic acid group in FcBA mediates complexation, while the Fe(II)/Fe(III) couple serves as a transducer. The diagnostic system, based on a miniaturized bare glassy carbon paste electrode (GCPE), has a fast response time.
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