Abstract
Application of 1-oleoyl-2-acetyl- sn-glycerol (OAG), an analogue of diacylglycerol (DAG) formed via M 3 muscarinic receptors, induced inward cationic currents via a protein kinase C-independent mechanism and produced membrane depolarization with increased action potential discharges in mouse intestinal myocytes. Outside-out patches from the myocytes responded to OAG with openings of 115-pS channels characterized by a mean open time ( O τ ) of 0.15 ms. M 3 receptor stimulation is reportedly capable of causing brief openings ( O τ = 0.23 ms) of 120-pS cationic channels in intestinal myocytes, thus the present results strongly support the idea that the M 3-mediated 120-pS channel opening is brought about via DAG-dependent mechanisms.
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