Abstract
Introduction: We report a rare case of non-insulin secreting malignant insulinoma of the pancreas and discuss its medical and surgical management.
 Case Presentation: Our patient was a 62- year-old Persian female. Over the previous year, she had developed increased abdominal mass, dizziness, weakness, and fatigue. After surgical operation, chemotherapy was given to the patient. Treatment with cisplatin and etoposide was commenced in a 4-month course.
 Conclusion: As a result, chemotherapy showed an important role in the management of insulinoma.
Highlights
We report a rare case of non-insulin secreting malignant insulinoma of the pancreas and discuss its medical and surgical management
Insulinoma accounts for only 1 percent of malignant pancreatic tumors and can occur with or without secretory function; and if it is combined with a hormonal syndrome, we considered it a secretory form 5
In non-secretory insulinoma, patients are asymptomatic until they develop gastric outlet obstruction or bile duct, or unless the tumor causes pain or are specified in imaging 6
Summary
We report a rare case of non-insulin secreting malignant insulinoma of the pancreas and discuss its medical and surgical management. Pancreatic endocrine tumors (PETs), with mild to moderate malignancies, originate from pancreatic islets. These tumors are rare and the prevalence is [1,2,3,4] per million people [1,2]. Insulinoma is the most common type and can be seen mostly in people between the ages of 30- to 60-year-old [3,4].
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