Abstract
BackgroundMetastatic pancreatic cancer has a dismal prognosis, with a mean six-month progression-free survival of approximately 50% and a median survival of about 11 months. Despite intensive research, only slight improvements of clinical outcome could be achieved over the last decades. Hence, new and innovative therapeutic strategies are urgently required. ParvOryx is a drug product containing native parvovirus H-1 (H-1PV). Since H-1PV was shown to exert pronounced anti-neoplastic effects in pre-clinical models of pancreatic cancer, the drug appears to be a promising candidate for treatment of this malignancy.MethodsParvOryx02 is a non-controlled, single arm, open label, dose-escalating, single center trial. In total seven patients with pancreatic cancer showing at least one hepatic metastasis are to be treated with escalating doses of ParvOryx according to the following schedule: i) 40% of the total dose infused intravenously in equal fractions on four consecutive days, ii) 60% of the total dose injected on a single occasion directly into the hepatic metastasis at varying intervals after intravenous infusions. The main eligibility criteria are: age ≥ 18 years, disease progression despite first-line chemotherapy, and at least one hepatic metastasis. Since it is the second trial within the drug development program, the study primarily explores safety and tolerability after further dose escalation of ParvOryx. The secondary objectives are related to the evaluation of certain aspects of anti-tumor activity and clinical efficacy of the drug.DiscussionThis trial strongly contributes to the clinical development program of ParvOryx. The individual hazards for patients included in the current study and the environmental risks are addressed and counteracted adequately. Besides information on safety and tolerability of the treatment after further dose escalation, thorough evaluations of pharmacokinetics and intratumoral spread as well as proof-of-concept (PoC) in pancreatic cancer will be gained in the course of the trial.Trial registrationClinicalTrials.gov-ID: NCT02653313, Registration date: Dec. 4th, 2015.
Highlights
Metastatic pancreatic cancer has a dismal prognosis, with a mean six-month progression-free survival of approximately 50% and a median survival of about 11 months
Hajda et al BMC Cancer (2017) 17:576 (Continued from previous page). This trial strongly contributes to the clinical development program of ParvOryx
Based on the findings described above, ParvOryx can reasonably be assumed to show efficacy against pancreatic cancer in humans
Summary
Metastatic pancreatic cancer has a dismal prognosis, with a mean six-month progression-free survival of approximately 50% and a median survival of about 11 months. The apparent mortality from pancreatic cancer has increased gradually in the past decades and was approximately 20 to 30% higher in 2014 than in 1970. This is probably due to an improvement of diagnostic procedures with a parallel increase in the number of properly documented disease cases. Pancreatic cancer is the only major cancer showing nearly no improvement of therapeutic outcome over the last decades [1,2,3]. There are no modalities for early diagnosis or screening for pancreatic cancer so that the disease is typically discovered only at advanced stages. The current standard of care for these tumor stages relies upon different chemotherapeutic regimens
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