Abstract
A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of imatinib mesylate from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD 0.999) between 20% to 100% of 500 mg of drug substance weight. The percentage recovery of imatinib mesylate in the optimized method was between 100.087 to 100.692%. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.
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