Abstract
This study aimed to develop a nomogram to predict fluorescence in situ hybridization (FISH) assay results for HER2-borderline breast cancer as determined via immunohistochemistry (IHC) among patients in China. We reviewed a database of breast cancer patients diagnosed between January 2007 and April 2013 at our institutions. We used logistic regression to develop a nomogram and we used receiver operating characteristic curve analysis and calibration plots to validate our nomogram. In total, 1138, 301 and 344 patients had IHC-determined HER2-negative, HER2-borderline and HER2-positive disease, respectively. Within the training cohort, univariate and multivariate analyses suggested that estrogen receptor (ER) status, progesterone receptor (PR) status and tumor grade were significantly associated with HER2 status (P<0.01). A nomogram was developed and the AUCs for the training and validation cohorts were 0.795 and 0.749, respectively. The calibration plots suggested that the model was well calibrated. This new nomogram can be used to predict HER2 status in HER2-borderline breast cancer patients and will be particularly helpful to resource-limited countries.
Highlights
Breast cancer is the most frequently diagnosed cancer and is the leading cause of cancer-related death among women
Univariate and multivariate analyses suggested that estrogen receptor (ER) status, progesterone receptor (PR) status and tumor grade were significantly associated with HER2 status (P
The HER2 status is crucial for the guidance of treatment decisions involving the use of trastuzumab, and measurement of the HER2 status is becoming a standard recommendation in the pretreatment work-up of patients with invasive breast cancer
Summary
Breast cancer is the most frequently diagnosed cancer and is the leading cause of cancer-related death among women. Determination of HER2 over-expression in breast carcinomas has become important in clinical practice, with the advent of antiHER2 therapy as demonstrated in clinical trials [5,6,7], such as the BCIRG 006, NSABP B31/N9831 and HEAR trials. All these trials have shown that trastuzumab can be beneficial to HER2-positive breast cancer patients. The HER2 status is crucial for the guidance of treatment decisions involving the use of trastuzumab, and measurement of the HER2 status is becoming a standard recommendation in the pretreatment work-up of patients with invasive breast cancer
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