Abstract
Coronary artery disease has emerged as one of the major diseases causing death worldwide. Coronary stent has great effect to improve blood flow to the myocardium subtended by that artery, in which bioresorbable vascular scaffolds are new-generation stents used by people. However, Coronary stents implantation has a risk of restenosis, which is relative to hemodynamic parameters. Most of existing literatures studied in this issue have not taken into account such important factors as the strut thickness and lumen profile, and has yet to analyze the time effects among hemodynamic parameters over a certain period of time based on individual models. In this research, we proposed a framework to assess the chronic impact of hemodynamic on coronary stent implantation. In the framework, the optical coherence tomography (OCT) is combined with angiography to reconstruct patient-specific models of bioresorbable vascular scaffolds. Then, the hemodynamics parameters are extracted through the simulated 3D models, obtaining the distribution of wall shear stress (WSS), relative residence time (RRT) and oscillatory shear index (OSI). Finally, the changes of these parameters representing the effectiveness of hemodynamics exerted on the implanted stent can be assessed to estimate the chronic impacts. By a 9-month follow-up case study, it is observed that the difference of hemodynamic parameters are not significance. Both at baseline and 9-month follow-up experiments show that the hemodynamic parameters remain normal and similar, proving that the coronary stent implantation nowadays appears to have a robust and everlasting curative effect.
Highlights
IntroductionArtery disease is the most common diseases
With the improvement of people’s living standard and longer life expectation, more and more people suffer from cardiovascular diseases because of individual health condition, age, hypertension and poor lifestyle habits, among which coronaryThe associate editor coordinating the review of this manuscript and approving it for publication was Ying Song.artery disease is the most common diseases
It is shown that in IVOCT images, the effective dilation of the vascular lumen after stent implantation does not result in restenosis at 9-month follow-up
Summary
Artery disease is the most common diseases. The dominating account of cardiovascular disease is atherosclerosis, which causes narrowing or obstruction of the vascular, resulting in myocardial ischemia, hypoxia. Coronary stent implantation is widely used as one of the most effective methods to treat acute vascular occlusion. The metal stent is permanently placed in the coronary artery lesion. The vascular wall is supported through balloon dilation or self-expand to keep the coronary artery lumen dilated, contributing to the low mortality of acute myocardial infarction. Bioresorbable coronary devices have been rapidly developed in recent years to overcome the limitations of the state-of-the-art drug-eluting permanent stents, including the risks of target lesion revascularization, neo-atherosclerosis, hindrance of late lumen enlargement, and the lack of reactive vasomotion in the stented vessel [6]. Bioabsorbable vascular scaffolds can be fully absorbed, decrease the risk of stent thrombosis
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