A női nemi hormonok szintje és a testzsírosság kapcsolata pubertáskorú leányoknál

Abstract

The main aims of the study were (1) to determine the normal range of salivary oestrogen and progesterone levels in subadult women by describing the pubertal pattern of gonadal sex hormone secretion; (2) to analyse the relationship between sex hormonal levels and body fat mass and body fat distribution in girls in the studied age interval; and (3) to analyse the relationship between body fatness and sexual maturation type by identifying early, average and late maturing girls on the basis of sex hormone levels, breast development and the occurrence of menarche. Hormonal and anthropomorphic data in girls across the pubertal spectrum (n: 100 girls, aged between 7 and 17 years) were collected in a cross-sectional study in 2016. The body fat fraction was estimated by InBody 720 body impedance analyser. The waist-to-hip ratio was used to assess the body fat distribution. The levels of free estradiol and free progesterone hormones were estimated by the 17β-Estradiol and Progesterone Saliva ELISA kits of IBL (Hamburg, Germany). A shift toward an increased level of salivary estradiol was found from the age 11, while the level of progesterone monotonically increased earlier from the age of 8 in the studied sample of healthy girls. By considering the relationship between body fatness indicators and gonadal hormonal levels, it can be stated that body fat mass significantly related to the level of salivary estradiol in the studied age interval of girls, the higher the level of estradiol, the higher amount of body fat was found. The body fat distribution did not show relation to the salivary level of the studied gonadal hormones in girls. The later the sexual maturation, the smaller amount of body fat mass was found in the studied age interval.