Abstract
Neuroscience![Figure][1] A methyl donor can reduce an addict's urge for ever more cocaine PHOTO: GBRUNDIN /ISTOCKPHOTO Relapse is a serious problem for many individuals trying to recover from addiction. Because DNA methylation regulates neural functions associated with synaptic plasticity, learning, and memory, Wright et al. investigated its role in sensitization to cocaine and reinstatement to cocaine and associated cues. A methyl donor, l-methionine, reduced behavioral sensitization to the locomotor-activating and drug-seeking effects of chronic cocaine use. l-methionine also blocked a cocaine-induced marker of neuronal activation after reinstatement in the nucleus accumbens and the medial prefrontal cortex, two brain regions responsible for drug seeking and relapse. J. Neurosci. , 35 , 8948 (2015). [1]: pending:yes
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
