Abstract
The bone marrow (BM) microenvironment allows for migration, growth, proliferation, and drug-resistant clonal evolution of multiple myeloma (MM) cells. BM adipocytes (BMAs) expand with aging and obesity, two key MM risk factors. BMAs are important contributors to systemic adipokine levels, bone health and hematopoiesis, and have also recently been implicated in acute myeloid leukemia. We investigated the interactions between MM cells and BMAs and found that adipocyte gene expression and cytokine secretion profiles are altered, creating a
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