Abstract
A new ursane-type triterpenoid, 20-taraxastene-22α-methoxy-3β-ol (1) together with nine known triterpenoids (2–10), was isolated from the leaves of Rhododendron dauricum L. Their structures were established from spectroscopic data (1D, 2D NMR, and HR-ESI-MS) and comparison with reported values. Among the isolates, compounds 1 and 8 were found in the family Ericaceae for the first time, and compounds 5, 6, and 10 from this species for the first time. All the isolated compounds were evaluated for their cytotoxic activities against three human cancer cells; compound 1 exhibited better cytotoxic activity against A549, HeLa, and SK-Hep1 cells than the other compounds with IC50 values of 34.04 ± 1.01, 64.04 ± 1.75, and 44.04 ± 0.05 μM, respectively.
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