Abstract
We have previously demonstrated that cell lines derived from a mouse teratocarcinoma source or a mouse blastocyst source produce procollagen and collagen, and suggested that this material may represent a new form of collagen specifically related to early embryonic development. We have now obtained further evidence using carboxymethyl cellulose chromatography, analytical isoelectric focusing, cyanogen bromide peptide analysis, amino acid analysis, and carbohydrate analysis that these two cell lines produce identical collagen molecular types which are distinctly different from types I, II, III, and IV collagen and thus probably represent a new type of collagen, called type V. All of these new data add support to the contention that these teratocarcinoma and blastocyst derived cells correspond to a cell present in the mouse embryo which may be a primitive or mesenchymal connective tissue cell type. Thus, these collagen and procollagen molecules may serve as a marker for cells of the early mouse embryo which are committed to the lineage of connective tissue.
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