Abstract

A new acetylated triterpenoid saponin elucidated as hederagenin‐3‐O‐β‐D‐xylopyranosyl (2→1)‐[3‐O‐acetyl‐α‐L‐arabinopyranosyl‐28‐O‐α‐L‐rhamnopyranosylester has been isolated from pericarps of Sapindus mukorossi Gaertn. The structure of the compound was determined by means of chemical and spectral analysis including advanced 2D NMR studies. The ethanolic extract from pericarps of the plant showed significant in vitro antimicrobial activity against various test organisms by Agar well diffusion method.

Highlights

  • Sapindus mukorossi Gaertn. of family Sapindaceae is wellknown soap nut tree, distributed in tropical and subtropical regions of Asia

  • Acetylated triterpenoid saponin was isolated from nn-butanol (BuOH) extract of the pericarps of S. mukorossi. e nn-BuOH extract was subjected to repeated column chromatography and the fractions were eluted with methanol in chloroform. e compound 1 was puri ed from among number of reported compounds with (50 mg) yield. e compound 1 was crystallized as an amorphous solid

  • Antimicrobial activity of ethanolic extract from pericarps of S. mukorossi was determined by the agar well diffusion method. e extract showed signi cant inhibitory activity against Esherichia faecalis, Pseudomonas aeuroginosa, Staphylococcus aureus, lcaligenes denitri cans, Klabsiella pneumoniae, Bacillus cereus, Pseudomonas alcaligenes, Micrococcus luteus, and Bacillus subtillis. e ethanolic extract showed most signi cant activity against Pseudomonas aeruginosa, Esherichia faecalis, and Bacillus cereus by inhibition zone diameter (IZD) value of 20, 19, and 17 mm, respectively, at minimum inhibitory concentration (MIC) of 100 μμg/mL, whereas the IZD values of 15, 17, and 15 mm, respectively, were shown at MIC value of 50 μμg/mL compared with positive control

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Summary

Introduction

Sapindus mukorossi Gaertn. of family Sapindaceae is wellknown soap nut tree, distributed in tropical and subtropical regions of Asia. Of family Sapindaceae is wellknown soap nut tree, distributed in tropical and subtropical regions of Asia. Fruits are popular ingredient in Ayurvedic shampoos and cleansers. E plant is an important remedy for relieving cough, detoxi cation, emetic, contraceptive, treatment of excessive salivation, epilepsy, and chlorosis [1,2,3]. Previous studies on the plants of this genus led to the isolation of triterpenoids, saponins [4,5,6,7] fatty acids [8], and avonoids [9]. E present paper illustrate the isolation and structure elucidation of a new acetylated triterpenoid saponin (1) (Figure 1) for the rst time from this species Previous studies on the plants of this genus led to the isolation of triterpenoids, saponins [4,5,6,7] fatty acids [8], and avonoids [9]. e present paper illustrate the isolation and structure elucidation of a new acetylated triterpenoid saponin (1) (Figure 1) for the rst time from this species

Result and Discussion
Findings
Experimental
Antimicrobial Assay
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