Abstract
Acute lung injury (ALI), a severe form of acute respiratory distress syndrome (ARDS), is characterized by an increase of vascular permeability that leads to alveolar and interstitial edema followed by hypoxemia. Diagnosis of ARDS is based on the visualization of pulmonary infiltrates by chest radiography or computed tomography (CT), however, any of these tools appear to be sufficiently efficient since 50% of ALI patients are misdiagnosed. Therefore, our aim is to evaluate dark-field imaging as a new tool to diagnostic in vivo early stages of ALI in a comparative study with conventional transmission imaging using an elastase-induced emphysema murine model.
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