Abstract

A New Tool for in vivo Manipulation of Brain microRNA Levels: The Work of Smalheiser et al. (2014)

Highlights

  • A commentary on Enoxacin elevates microRNA levels in rat frontal cortex and prevents learned helplessness by Smalheiser NR, Zhang H, Dwivedi Y

  • Smalheiser, Zhang, and Dwivedi describe a rat model that may provide these tools for studying molecular mechanisms of major depressive disorder (MDD)

  • Major depressive disorder encompasses a wide range of neurological symptoms, perhaps reflecting the wide variety of cellular and molecular alterations which have been reported in multiple brain regions [1]

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Summary

Introduction

A commentary on Enoxacin elevates microRNA levels in rat frontal cortex and prevents learned helplessness by Smalheiser NR, Zhang H, Dwivedi Y. Smalheiser, Zhang, and Dwivedi describe a rat model that may provide these tools for studying molecular mechanisms of major depressive disorder (MDD).

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