Abstract

A novel Co(II)-based metal-organic framework (MOF) {[Co2(TCPP)(BPY)](DMF)3}n (1) with a pillared structure based on 2,3,5,6-tetrakis(4-carboxyphenyl)pyrazine (H4TCPP) and 4,4′-bipyridine (BPY) is designed and synthesized via the solvothermal reaction. Furthermore, a green-hand grinding technique is implemented to reduce the particle size of complex 1 to generate nanoscale 1 (denoted as nano-1 hereafter). After the construction of the acute cerebral infarction animal model, the infarct area of the brain is measured after 2 weeks of treatment with the compound. Then, ELISA is performed to detect the content of hs-CRP and IL-1β and TNF-α in the serum.

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