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Abstract
Some drugs that regulate estrogen are currently used as therapy for endometriosis. However, these medical treatments have significant side effects and patients who hope to become pregnant cannot overcome infertility. To compare morphological alterations and clinical symptoms, revised American Fertility Society (r-AFS) scores were compared between patients with and without leukotriene receptor antagonist (LTR-A) treatment. LTR-A-treated cases showed significantly decreased r-AFS score. Furthermore, a significant correlation was seen between r-AFS score and LTR-A treatment period. In treated cases, clinical symptoms decreased and some patients achieved pregnancy. Morphologically, lesions in LTR-A-treated cases showed apoptotic fibroblasts and degeneration of collagen fibers. Our findings revealed that LTR-As had significant therapeutic value for the treatment of human endometriosis. Anti-LT therapy appears efficacious not only in the treatment of clinical symptoms and lesions, but also in improving fertility.
Highlights
Endometriosis is a disease characterized by the ectopic presence of endometrial tissue
With regard to the evaluation of pain, we investigated the quantity of prescribed nonsteroidal anti-inflammatory drugs (NSAIDs) for 19 patients on leukotriene receptor antagonist (LTR-A) who complained of dysmenorrhea and had taken NSAIDs customarily, and performed evaluations using the nonparametric one-sample sign test
With regard to clinical symptoms, LTR-A treatment made the amount of taken NSAIDs for 19 patients, who complained of pelvic pain including dysmenorrhea, decrease as follows; eight of the 19 patients reported decreased ingestion of prescribed NSAIDs, and five of the 19 patients took no NSAIDs
Summary
Endometriosis is a disease characterized by the ectopic presence of endometrial tissue. Patients with the condition show severe adhesions on the pelvic organs and peritoneal surfaces, and clinically they experience dysmenorrhea. The progression of endometriosis is linked to estrogen [1], so drugs that regulate estrogen are in current. How to cite this paper: Sugamata, M., Ihara, T. and Uchiide, I. (2015) A New Therapy for Human Endometriosis: The Therapeutic Value of Leukotriene Receptor Antagonist for Endometriosis. Open Journal of Obstetrics and Gynecology, 5, 313-318. These pharmacotherapies have significant side effects, and patients often discontinue therapy. Inasmuch as endometriosis is closely related to infertility [2], development of more tolerable therapies for infertility patients with this condition is imperative
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