Abstract
Non inferiority of one diagnostic method to another is a common issue in medical research. This article proposes a new test using an approximate p-value, which is based on only one point of the two-dimension nuisance parameter space. The sizes and powers of our test, the asymptotic normal test,Sidik and Hsueh's unconditional exact tests are considered. Simulation results suggest that our test can definitely control the Type I error rates with reasonable powers under all studied conditions while the asymptotic normal test cannot for most cases. Compared to Sidik and Hsueh's tests, our test is much easier to implement.
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