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Abstract
G protein-coupled receptor stimulation inhibits TRPM3 channel activity through direct binding of the Gβγ subunit to the channel.
Highlights
M any of the cells in our body communicate by releasing small molecules that bind to receptors on the surface of target cells
Heterotrimeric G proteins – protein complexes that consist of three different subunits named a, b and g – provide one such pathway, and work with cell surface receptors called G protein-coupled receptors (GPCRs; Figure 1A)
When the complex interacts with an activated GPCR, the molecule of GDP is exchanged for GTP, and the G protein complex dissociates into two parts: Ga-GTP and a stable Gbg dimer
Summary
M any of the cells in our body communicate by releasing small molecules that bind to receptors on the surface of target cells. G protein bg subunits inhibit TRPM3 ion channels in sensory neurons. Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels.
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