A new system to perform continuous target tracking for radiation and surgery using non-ionizing alternating current electromagnetics

Abstract

A new technology based on alternating current (AC) nonionizing electromagnetic fields has been developed to enable precise localization and continuous tracking of mobile soft tissue targets or tumors during radiation therapy and surgery. The technology utilizes miniature, permanently implanted, wireless transponders (Beacon™ Transponders) and a novel array to enable objective localization and continuous tracking of targets in three-dimensional space. The characteristics of this system include use of safe, nonionizing electromagnetic fields; negligible tissue interaction, delivery of inherently objective three-dimensional data, continuous operation during external beam radiation therapy or surgery. Feasibility testing has shown the system was capable of locating and continuously tracking transponders with submillimeter accuracy at tracking rates of up to 10 Hz and was unaffected by operational linear accelerator. Preclinical animal studies have shown the transponders to be suitable for permanent implantation and early human clinical studies have demonstrated the feasibility of inserting transponders into the prostate. This system will enable accurate initial patient setup and provide real-time target tracking demanded by today's highly conformal radiation techniques and has significant potential as a surgical navigation platform.