A new synthetic route to fluorinated pyrazolo[3,4-b]pyridines and their use in the preparation of novel pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidines

Abstract

A single-step synthesis of 3-amino-4-trifluoromethyl-6-substituted-1 H-pyrazolo[3,4-b]pyridines ( 7) from 2- O-acetamido-3-cyano-4-tri-fluoromethyl-6-substituted pyridines ( 6) is described, and their use in the synthesis of novel pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidines ( 8) under microwave irradiation outlined.