Abstract
Several structural analogues of strobilurin A having general formula (E)- 18 , in which the methyl ( E)-3-methoxypropenoate unit is linked to substituted aromatic, alkenyl or cyclopentenyl substrates, have been efficiently and selectively prepared by Pd-catalyzed cross-coupling reactions between ( Z)-2-methoxy-1-(methoxycarbonyl)ethenylzinc halides, (Z)- 19 , and aryl halides, alkenyl halides or triflates or cyclopentenyl triflates, respectively. Compounds (Z)- 19 , which represent a new class of highly functionalized and stereodefined organozinc derivatives, have been synthesized in very high yield by reaction of THF solutions of easily available methyl ( Z)-2-iodo- or ( Z)-2-bromo-3-methoxypropenoate, (Z)- 8 and (Z)- 12 , respectively, with an activated Zn Ag couple in the presence of TMEDA. Compounds (E)- 18 synthesized according to this procedure include substances which are known to be able to control agrochemically important fungi as well as derivatives which are able to inhibit the growth of fungi which deteriorate papery materials.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
