Abstract
Background: Metabolic Syndrome (MS) is considered a cluster of metabolic abnormalities whose pathogenesis is principally attributable to insulin resistance. Lack of estrogens occurs in postmenopausal women and worsening insulin resistance and lipid profile, predispose to MS. The aim of the study was to show whether a new supplement containing cinnamon, corosolic acid and glycyrrhizic acid may counteract MS manifestations. Methods: A total of 60 postmenopausal women were enrolled in a randomized, controlled trial; the active treatment group was taking the new supplement for 3 months and was on a hypocaloric diet, control group was only on diet. At the beginning and after 3 months, metabolic variables were evaluated. Results: After 3 months, a significant difference in the treated group was observed for glucose, HOMA, total cholesterol and HDL-cholesterol; whereas, in the control group, a significant difference was shown only for glucose. After 3 months, a significant difference between groups was highlighted only for HDL-cholesterol. Conclusion: This study has shown the naturally occurring components of this new supplement may improve insulin resistance and lipid profile in a small sample of postmenopausal women.
Highlights
The two groups were comparable for age: 55.8 ± 5.5 (TG) vs. 56.9 ± 5.6 years in the control group (CG) (p = 0.5), and time elapsed from the last period: 81.4 ± 61 months in the treated group (TG) and 95.6 ± 66.7 months in the CG (p = 0.4)
At the end of the study, no statistically significant differences were found in the two groups regarding anthropometric variables, such as BMI and waist circumference, and for some metabolic measures such as insulin, triglycerides, and blood pressure and thyroid profile (Table 1)
After 3 months, a significant difference in the TG was highlighted for glucose (Figure 1), Homeostasis Model Assessment (HOMA)-IR (Figure 2), total cholesterol (TC) (Figure 3) and HDL-C (Figure 4)
Summary
It is defined by four clinical manifestations: central obesity, glucose intolerance, dyslipidemia and high blood pressure. There is an increased request of natural compounds to prevent or to treat metabolic disorders too Some of these substances are Corosolic Acid, Glycyrrhizic Acid and Cinnamon. These supplements were already individually used in oriental traditional medicine as a remedy for various illnesses and ailments, for lowering blood glucose levels, reducing body weight and treating metabolic diseases, such as DM. Conclusion: This study has shown the naturally occurring components of this new supplement may improve insulin resistance and lipid profile in a small sample of postmenopausal women
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