A new strategy for the synthesis of coumarin- and quinolone-annulated pyrroles via Pd(0) mediated cross-coupling followed by Cu(I) catalyzed heteroannulation

Abstract

The sequential coupling and cyclization reactions between aryl halides and (trimethylsilyl)acetylene (TMSA) with concurrent elimination of the TMS substituent, allows a straightforward synthesis of substituted pyrano[3,2- e]indolone and pyrrolo[3,2- f]quinolone derivatives in excellent yields.