Abstract
AbstractA novel organocatalytic method for the stereoselective synthesis of highly substituted cyclopropanes is reported. The Michael adducts, generated through the addition of α‐substituted cyanoacetates to easily accessible vinyl selenones catalyzed by a bifunctional ureidic catalyst, smoothly cyclize by intramolecular alkylation induced by a de‐ethoxycarbonylation process. The one‐pot sequence generates cyclopropanes bearing adjacent tertiary and quaternary stereocentres as single Z‐isomers in moderate to high yields and good enantiomeric excesses.
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