Abstract
Macitentan is an endothelin receptor antagonist drug used in the treatment of pulmonary arterial hypertension (PAH). PAH is defined as a serious disease of the arteries (pulmonary arteries) that connect the lungs to the heart. The aim of our study is to develop and validate a new, sensitive, simple, accurate and reliable UV spectrophotometric method for the quantification of macitentan in human plasma. Using a wavelength of 269 nm, macitentan was quantitatively analyzed. For standard solution concentrations of 1–30 μg/mL and for human plasma concentrations of 2–30 μg/mL, respectively, the method was linear. By computing the correlation coefficient, linearity was determined. In standard solution and human plasma, these values were found to be 0.9996 and 0.9991, respectively. In terms of accuracy, sensitivity, precision, and repeatability, the developed spectrophotometric method was deemed satisfactory. In addition to this, this method could be directly and easily applied to both bulk and human plasma.
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