Abstract
A simple sensitive visible spectrophotometric method, an alternative to the existing UV spectrophotometric method of the U.S. Pharmacopoeia, for the determination of microgram quantities of free salicylic acid in aspirin and its formulations based on the formation of a color by oxidative coupling of 3-methylbenzthiazolinone-2-hydrazone with salicylic acid is presented. Nonphenolic compounds and common excipients present in the formulations do not interfere with the proposed method. The proposed method gives reproducible and accurate results comparable with the established pharmacopoeial method.
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