Abstract
A NEW species of double-stranded RNA has been detected in certain strains of bakers' yeast, Saccharomyces cerevisiae, during investigations of the chemical nature of the cytoplasmic genetic determinants concerned with the killer character in yeast. There are three phenotypes with respect to this killer phenomenon: killer, sensitive and neutral. Killer cells kill sensitive cells by secreting into the medium a toxic polypeptide1,2 to which they themselves are immune. Neutral cells neither kill nor are killed. The phenomenon is under the control of at least one nuclear gene and two types of cytoplasmic determinant, (k) and (n), which confer the killer and neutral phenotypes respectively3–5.
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