A new simple electrochemical Moxifloxacin Hydrochloride sensor built on carbon paste modified with silver nanoparticles

Abstract

A new sensitive simple electrochemical sensor for Moxifloxacin Hydrochloride (MOXI) detection has been successfully performed. The sensor built on carbon paste (CP) modified with silver nanoparticles (AgNPs). AgNPs are biocompatible stable noble materials especially in biological sensing. The silver nanoparticles modified carbon paste electrode (SNMCPE) displayed high electrocatalytic activity towards oxidation of 1.0mM MOXI in Britton Robinson (BR) buffer of pH range (2.0–9.0). The techniques used to do this work are cyclic voltammetry (CV), linear sweep voltammetry (LSV), chronoamperometry (CA) and electrochemical impedance spectroscopy (EIS). Surface characteristics were achieved using scanning electron microscopic (SEM) and Energy Dispersive X-Ray Analysis (EDX) techniques. The effect of changing MOXI concentration (7.0×10−7 to 1.8×10−4M) was studied in BR buffer (pH =7.4) at a scan rate of 50mV/s using SNMCPE. The detection and quantification limits were found to be 2.9×10−9M and 9.6×10−8M, respectively. In order to assess the applicability of MOXI detection method in real samples; this method was tested in Delmoxa tablet and human urine sample. Good sensible results were attained for MOXI detection.