Abstract
Treatment of a free amino acid ester with CO 2 followed by exposure to a chlorosilane-containing polystyrene results in its attachment to the solid support. The newly formed silyl carbamate can be employed to build polypeptides at the carboxyl terminus. Cleavage of the (poly)peptide using aqueous HF in CH 3CN leads to its free amine form which is isolated as a Boc derivative. The polymer support can be easily recycled.
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