Abstract
Sponges are a well-known bioresource for bioactive compounds. In this study, antibacterial activity-guided fractionation of the extract from an Indonesian marine Dactylospongia elegans sponge led to the discovery of four merosesquiterpenoids, namely, a new sesquiterpenoid aminoquinone nakijiquinone V (1), along with illimaquinone (2), smenospongine (3), and dyctioceratine C (4). The structure of compound 1 was elucidated by 1D and 2D NMR as well as by LC-HRESIMS data analysis. Compounds 2–4 showed moderate to low antimicrobial activity against Bacillus megaterium DSM32 with a minimum inhibitory concentration (MIC) of 32 μg/mL, 32 μg/mL, and 64 μg/mL, respectively. Furthermore, compounds 2 and 3 both inhibited Micrococcus luteus ATCC 4698 with a MIC of 32 μg/mL. In conclusion, the isolated merosesquiterpenoids, which are known for their cytotoxic effects, showed antibacterial activity and prompt future structure activity relationship (SAR) studies concerning the various bioactivities observed for this group of natural products.
Highlights
A New Sesquiterpenoid Aminoquinone from an Indonesian Marine SpongeWalter Balansa 1,2 , Ute Mettal 1,3 , Zerlina G
Sponges are a prolific source of bioactive compounds [1,2,3,4,5,6,7]; in particular, the genera Dysidea, Spongia, and Dactylospongia represent a rich source of bioactive sesquiterpenoid quinones and hydroquinones [8]
During our ongoing search for new antibiotic compounds from Indonesian marine sponges, we investigated the extract of a sponge specimen, identified as Dactylospongia elegans based on 28S
Summary
Walter Balansa 1,2 , Ute Mettal 1,3 , Zerlina G. Wuisan 1,3 , Anuchit Plubrukarn 4 , Frans G. Ijong 2,5 , Yang Liu 1,3, * and Till F. Faculty of Fisheries and Marine Science, Sam Ratulangi University, Manado 95115, Indonesia
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