Abstract
Monitoring tamoxifen as an anticancer drug with high side effects is so important in the chemotropic process. In this regard, a fast and simple electrochemical sensor was fabricated using a carbon paste electrode (CPE) modified with 1-octyl-3-methylimidazolium chloride (OMIC) and Fe3O4/graphene nanocomposite and utilized for tamoxifen monitoring. Fe3O4/graphene nanocomposite (Fe3O4-GR) was synthesized by a one-pot synthesis approach, following by then characterized by FESEM and EDS methods. The Fe3O4-GR/OMIC/CPE offered catalytic activity on the redox reaction of tamoxifen and enhanced its oxidation current about 4.59 times. Moreover, the high electrical conductivity of mediators aided the reducing the oxidation potential of tamoxifen (about 80 mV) compared with the unmodified electrode. In addition, Fe3O4-GR/OMIC/CPE showed a linear dynamic range of 0.01 µM – 150 µM with a detection limit of 7.0 nM for sensing of tamoxifen using the square wave voltammetric method. Furthermore, Fe3O4-GR/OMIC/CPE displayed a superior ability for sensing tamoxifen in real samples with an acceptable recovery range. In brief, Fe3O4-GR/OMIC/CPE provided good selectivity for sensing f tamoxifen in an aqueous solution in the presence of organic and inorganic interferences.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have