Abstract
Abstract The aim of this work is to develop and validate a simple, sensitive, rapid and accurate and less time consuming validated RP-HPLC method for Etodolac and Thiocolchicoside in pharmaceutical dosage form. The method was developed and validated for various parameters as per ICH guidelines. The results obtained were within the acceptance criteria. The proposed method was applied for the determination of Etodolac and Thiocolchicoside in marketed formulation. The assay results confirm with the label claim of formulation.. Hence, the proposed method was found to be satisfactory and could be used for the routine analysis of Etodolac and Thiocolchicoside in combined tablet dosage forms. The retention time were found to be was 2.777 and 2.380 min for Etodolac and Thiocolchicoside respectively. The quantitative estimation gave a satisfactory result for Etodolac (99.66 % w/w) and Thiocolchicoside (99.3% w/w) respectively. The regression values over its peak areas were found to y = 17537x + 361.5 and y = 17769x + 1505 respectively and correlation coefficient found to be about 0.9999 and 0.9998 for Etodolac and Thiocolchicoside respectively. The percentage recovery for Etodolac and Thiocolchicoside were found to be 99.99% and 101.2 % respectively
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