Abstract
Highly potent and biologically active 2-phenylpyridine and its derivatives were synthesized selectively in single step from acetophenone and allyl alcohol in presence of ammonia over molecular sieve catalysts at 360 °C. Mesoporous Al-MCM-41 is found to be good catalyst towards cyclization when compared to microporous HY, HX, Hβ and HZSM-5 catalysts. A plausible mechanism leading to the synthesis of 2-phenylpyridine in a single step is highlighted.
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