Abstract
Our view of the nuclear pore complexes (NPCs) as gateways between the nuclear and cytoplasmic compartments has been largely expanded in recent years. NPCs have now demonstrated roles in genome regulation and maintenance from single cells to multicellular organisms. Both NPC proteins as well as components of the NPC basket act as dynamic scaffolds for silencing factors, and chromatin and cell cycle regulators. Components of the NPC basket also couple mRNA production and export, and prevent the exit of unprocessed mRNAs from the nucleus. Our recent work describes a novel function of the fission yeast nuclear basket component - the translocated promoter region (TPR) nucleoporin Alm1 - in proper localization of the proteasome to the nuclear envelope. Here we discuss how regulation of proteasome localization to the nuclear envelope by Alm1 is key to maintain kinetochores homeostasis and proper chromosome segregation.
Highlights
The nuclear envelope (NE) is a bilayer membrane that separates the DNA-containing nucleoplasm from the cytoplasm
Our recent work describes a novel function of the fission yeast nuclear basket component - the translocated promoter region (TPR) nucleoporin Alm1 - in proper localization of the proteasome to the nuclear envelope
The assembly of transcriptional complexes at the nuclear periphery is mediated by the nuclear basket: Mlp1 binds the SAGA (Spt-Ada-Gcn5acetyltransferase) chromatin-modifying complex, whereas Nup1 interacts with the TREX-2 (Transcription Elongating and RNA Export) complex
Summary
The nuclear envelope (NE) is a bilayer membrane that separates the DNA-containing nucleoplasm from the cytoplasm. Both NPC proteins as well as components of the NPC basket act as dynamic scaffolds for silencing factors, and chromatin and cell cycle regulators. Our recent work describes a novel function of the fission yeast nuclear basket component - the translocated promoter region (TPR) nucleoporin Alm1 - in proper localization of the proteasome to the nuclear envelope.
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