Abstract
A new role for inflammasomes: sensing the disturbances in non-alcoholic fatty liver disease.
Highlights
Non-alcoholic fatty liver disease (NAFLD) is a manifestation of metabolic syndrome, a group of conditions including hypertension, high plasma glucose, excess body fat around waist or abnormal cholesterol levels which will work together to increase the risk of heart disease, diabetes, and stroke (Kim and Younossi, 2008)
Since the major aim of this study was to determine the cause of progression of NAFLD in Metabolic Syndrome, mice were fed a methionine-choline-deficient diet (MCDD) to induce FLD
When inflammasome-deficient MCDD mice were cohabited with wild type (WT) mice, the dysbiosis and manifestation of disease were transferred over to the WT mice
Summary
Non-alcoholic fatty liver disease (NAFLD) is a manifestation of metabolic syndrome, a group of conditions including hypertension, high plasma glucose, excess body fat around waist or abnormal cholesterol levels which will work together to increase the risk of heart disease, diabetes, and stroke (Kim and Younossi, 2008). An exciting but different way at looking at the progression of NAFLD to NASH has been conducted by Henao-Mejia et al (2012). Though the association between intestinal dysbiosis and progression of FLD has been studied in the past, Henao-Mejia et al suggest that gut dysbiosis may be the driver of this progression, not just an association.
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