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Abstract
A New Role for a Long-Studied DNA-Wrangling Enzyme
Highlights
In the ongoing search for promising cancer drugs, researchers often discover effective therapies before knowing precisely how they work
Paula Coelho et al investigated the role of topoisomerase II (TOPO II) in a critically important step in the cell cycle—the separation of the duplicated chromosomes— and made a surprising discovery
Chromosomes to segregate properly, sister kinetochores must hook up to microtubules from spindle poles oriented toward opposite poles
Summary
In the ongoing search for promising cancer drugs, researchers often discover effective therapies before knowing precisely how they work. Cohesins tie the sister chromatids together for alignment and attachment to the mitotic spindle—a spider-like array of microtubule proteins—via specialized structures called kinetochores, protein complexes that bind the chromosome’s centromere to connect sister chromatids to the spindle. Depletion of TOPO II results in syntelic kinetochore attachments (with kinetochores on the same spindle pole), non-disjunction, and highly reduced Aurora B kinase activity.
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