Abstract
Aim To study the constituents and bioactivity of Illicium simonsii. Methods The extracts of the fruits of Illicium simonsii were submitted to a combination of chromatographic materials, silica gel, ODS column chromatography and finally preparative HPLC to obtain eight compounds which were further evaluated for their cytotoxicity by MTT method. Results A new phenylpropanoid glycolside, 2, 4-dihydroxy-allylbenzene-2- O-β-D-glucopyranoside ( 1), together with seven characteristic sesquiterpene lactones, oligandrumin B ( 2), oligandrumin D ( 3), anisatin ( 4), veranisatin D ( 5), pseudomajucin ( 6), 1α-hydroxy-3-deoxy-pseudoanisatin ( 7), 8α-hydroxy-10-deoxycyclomerrillianolide ( 8) were isolated. Conclusion Compound 1 is new. Compounds 1, 2, 3, 5–8 were isolated from this plant for the first time. None of the isolates showed inhibitory effects on the growth of non-small cell lung tumor cell line A549.
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