Abstract
AbstractWe develop a new dimensionless representation of the time‐dependent mass balances for the Michaelis–Menten (MM) reaction mechanism; we identify several dimensionless parameters that control the fundamental nature of the solution; and we solve the scaled equations with a combined regular and singular perturbation expansion. Unlike several approximate solutions to the MM problem offered previously in the literature, each of which is valid only for some limited range of conditions, the new solution converges accurately for any combination of initial substrate concentration, initial enzyme concentration, and kinetic rate constants. We discuss the physical significance and interdependence of the dimensionless parameters that emerge from our scaling analysis; we use these parameters to categorize previous approximations for the MM problem and to delimit their accuracy; and we verify the accuracy of our solution via comparisons to an exact numerical solution and various approximations offered previously by others. © 2008 American Institute of Chemical Engineers AIChE J, 2008
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
