Abstract
Sleep disturbances, as well as sleep-wake rhythm disorders, are characteristic symptoms of Alzheimer's disease (AD) that may head the other clinical signs of this neurodegenerative disease. Age-related structural and physiological changes in the brain lead to changes in sleep patterns. Conditions such as AD affect the cerebral cortex, basal forebrain, locus coeruleus, and the hypothalamus, thus changing the sleep-wake cycle. Sleep disorders likewise adversely affect the course of the disease. Since the sleep quality is important for the proper functioning of the memory, impaired sleep is associated with problems in the related areas of the brain that play a key role in learning and memory functions. In addition to synthetic drugs, utilization of medicinal plants has become popular in the treatment of neurological diseases. Curcuminoids, which are in a diarylheptanoid structure, are the main components of turmeric. Amongst them, curcumin has multiple applications in treatment regimens of various diseases such as cardiovascular diseases, obesity, cancer, inflammatory diseases, and aging. Besides, curcumin has been reported to be effective in different types of neurodegenerative diseases. Scientific studies exclusively showed that curcumin leads significant improvements in the pathological process of AD. Yet, its low solubility hence low bioavailability is the main therapeutic limitation of curcumin. Although previous studies have focused different types of advanced nanoformulations of curcumin, new approaches are needed to solve the solubility problem. This review summarizes the available scientific data, as reported by the most recent studies describing the utilization of curcumin in the treatment of AD and sleep deprivation-related consequences.
Highlights
Plants have a long history of use as a remedy for numerous health problems
Despite the fact that rivastigmine and galantamine do not disrupt sleep, there is limited evidence that cholinesterase inhibitors improve sleep in Alzheimer's patients. Against this backdrop of evidence suggesting that cholinesterase inhibitors may have limited utility as explicit medications for improving nighttime fomentation and sleep in Alzheimer's disease, a few reports recommend their use in the treatment of dream enactment behaviors associated with Lewy body dementia (LBD) [92, 93]
This information is persistent with frequent cortical cholinergic loss in LBD that is in some point, in excess of that seen in Alzheimer’s disease (AD)
Summary
Plants have a long history of use as a remedy for numerous health problems. When we look at the traditional treatments, Curcuma longa L. (Zingiberaceae), commonly known as turmeric, comes to the fore. A natural compound isolated from C. longa, has multiple applications in treatment of various diseases such as cardiovascular diseases [3], liver disease [4, 5], obesity [6, 7], cancer [8], inflammatory diseases [9, 10], and aging [11, 12]. Besides these applications and activities, curcumin has been reported to be effective in many neurodegenerative diseases. Recent review studies on this area are very important and can provide researchers with new perspectives
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